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位置: 首页> 品牌> Sigma-Aldrich> VU0240551

VU0240551

品牌
Sigma-Aldrich
CAS
893990-34-6
货号
V3890
包装型号
规格纯度
≥98% (HPLC)
价格
2151.18 *本价格含增值税费
促销
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半岛bd体育手机客户端 名称:
893990-34-6
VU0240551
VU0240551-2-D4
N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-acetamide
CID 7211972
VU0240551-1
SID 56405457
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

包装

5, 25 mg in glass bottle

生化/生理作用

VU0240551 is a potent, selective KCC2 inhibitor. KCC2 is a potassium-chloride exchanger expressed specifically in neurons. KCC2 functions to lower intracellular chloride concentrations below the electrochemical potential of the cells, thereby increasing the hyperexcitability of the neurons. KCC2 activity enhances GABA and other inhibitory neurotransmission and is implicated in pain processing. VU0240551 was discovered in a high-throughput screen, followed by directed medicinal chemistry. VU0240551 is selective for KCC2 over NKCC1. VU0240551 binds competitively to the K+ site and binds noncompetitively to the Cl- site. VU0240551 is the only small molecule with specificity for a KCC family member.

基本信息

经验(实验)分子式 C16H14N4OS2
分子量 342.44
MDL编号 MFCD05957363
PubChem化学物质编号 329829046
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
溶解性 DMSO: >20 mg/mL
储存温度 2-8℃
SMILES string Cc1csc(NC(=O)CSc2ccc(nn2)-c3ccccc3)n1
InChI 1S/C16H14N4OS2/c1-11-9-23-16(17-11)18-14(21)10-22-15-8-7-13(19-20-15)12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H,17,18,21)
InChI key WJRWSLORVIHRNX-UHFFFAOYSA-N

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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