半岛bd体育手机客户端 说明
包装
5, 25 mg in glass bottle
生化/生理作用
Vosaroxin is an anti-cancer quinolone derivative that acts as a DNA intercalator and a topoisomerase II inhibitor, causing p53 independent tumor cell apoptosis. Vosaroxin stabilizes cleavage complexes formed by topoisomerase IIα and IIβ, which results in an accumulation of DNA double-strand breaks. Vosaroxin showed antineoplastic activity in multiple solid tumor and hematologic cancer cell lines and has been in clinical trials for AML.
基本信息
| 经验(实验)分子式 | C18H19N5O4S · HCl |
| 分子量 | 437.90 |
| MDL编号 | MFCD13185156 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 旋光性 | [α]/D +42 to +52°, c = 1 in 0.1 M NaOH |
| 颜色 | white to beige |
| 溶解性 | H2O: 1 mg/mL, clear (warmed) |
| 储存温度 | ?20℃ |
| SMILES string | O=C(C(C(O)=O)=C1)C2=C(N=C(C=C2)N3C[C@@H]([C@H](C3)NC)OC)N1C4=NC=CS4 |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
