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UPCDC30245

品牌
Sigma-Aldrich
CAS
1883351-01-6
货号
SML1674
规格纯度
≥98% (HPLC)
价格
1827.11 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
1883351-01-6
UPCDC30245
1-(3-(5-Fluoro-1H-indol-2-yl)phenyl)-N-(2-(4-isopropylpiperazin-1-yl)ethyl)piperidin-4-amine
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

包装

5, 25 mg in glass bottle

生化/生理作用

UPCDC30245 is an allosteric inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). p97 is an integral component of the ubiquitin fusion degradation (UFD) pathway. It plays a role in degradation of misfolded proteins, Golgi membrane reassembly, membrane transport, myofibril assembly, autophagosome maturation, and cell division, and is overexpressed in many tumor types. UPCDC30245 has an IC50value of 27 nM, and has been shown to bind at the junction between the D1 and D2 domains of p97. UPCDC30245 has been used in cryo-ECM to show how such inhibitor binding prevents the confomational changes necessary for p97 function.

基本信息

经验(实验)分子式 C28H38FN5
分子量 463.63
PubChem化学物质编号 329826009

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 30 mg/mL, clear
储存温度 2-8℃
SMILES string FC1=CC=C(NC(C2=CC=CC(N3CCC(NCCN4CCN(C(C)C)CC4)CC3)=C2)=C5)C5=C1

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H315 - H319 - H335
预防措施声明 P305 + P351 + P338
危险分类 Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官 Respiratory system
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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