半岛bd体育手机客户端 说明
包装
5, 25 mg in glass bottle
生化/生理作用
Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.
制备说明
UA62784 is soluble in DMSO at a concentration >2 mg/ml.
基本信息
| 经验(实验)分子式 | C23H15NO3 |
| 分子量 | 353.37 |
| MDL编号 | MFCD00489199 |
| PubChem化学物质编号 | 329827627 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | yellow |
| 溶解性 | DMSO: >2 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34 |
| InChI | 1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3 |
| InChI key | SVICLWPFAQYZLX-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 |
| 危险分类 | Acute Tox. 4 Oral |
| 储存分类代码 | 11 - Combustible Solids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
