Tyrphostin 1

半岛bd体育手机客户端 说明

应用

Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells.

包装

25 mg in poly bottle

生化/生理作用

Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation,. Furthermore, studies have reported that tyrphostin 1 can block Ca²⁺channels and inhibit growth in vascular smooth muscle cells,.
EGFR tyrosine kinase inhibitor.

特点和优势

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制备说明

Tyrphostin 1 dissolves in chloroform at 50 mg/ml to yield a clear, light yellow solution. It is also soluble in DMSO.

基本信息

线性分子式	CH3OC6H4CH=C(CN)2
分子量	184.19
MDL编号	MFCD00019787
PubChem化学物质编号	24278751
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	200
测定	≥98%
形式	solid
效能	>1250 μM IC50(negative control)
mp	113-116 ℃ (lit.)
溶解性	chloroform: soluble 50 mg/mL, clear, light yellow DMSO: soluble
储存温度	2-8℃
SMILES string	COc1ccc(cc1)\C=C(/C#N)C#N
InChI	1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3
InChI key	UOHFCPXBKJPCAD-UHFFFAOYSA-N
Gene Information	human ... EGFR(1956)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)