半岛bd体育手机客户端 说明
生化/生理作用
TY-52156 is a potent sphingosine 1-phosphate (S1P) receptor 3 (S1P3; S1PR3) antagonist that selectively inhibits S1P-stimulated Ca2+ response in human S1P3-expressing cells (Ki = 110 nM) and Eu-GTP binding to S1P3-containing membranes over those of S1P1/2/4/5. TY-52156 inhibits S1P3-dependent signaling events in human coronary artery smooth muscle cells (1 μM), S1P3-dependent coronary flow decrease in perfused rat hearts, as well as S1P3-mediated acute mechanical pain in mice (10 nmol/20 μL/paw id.) and bradycardia in anesthetized rats (30 mg/kg TY-52156 p.o.)in vivowith good oral bioavailability (F = 70.9%; 1 mg/kg p.o. in rats).
基本信息
| 经验(实验)分子式 | C18H19Cl2N3O |
| 分子量 | 364.27 |
半岛bd体育手机客户端 性质
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to very dark brown |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | CC(C)(C(/C(NC1=CC=C(C=C1)Cl)=N/NC2=CC=C(C=C2)Cl)=O)C |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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