TUG-424

半岛bd体育手机客户端 说明

包装

5, 25 mg in glass bottle

生化/生理作用

TUG-424 is expected to be useful in the exploration of FFA1 and may also be valuable as a lead structure for new potential antidiabetic therapeutics. TUG-424 significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity. It enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1.

GPR40 (now FFA1) was formerly an orphan GPCR whose endogenous ligands have recently been identified as free fatty acids (FFAs). The receptor appears to be involved in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release.

基本信息

经验(实验)分子式	C18H16O2
分子量	264.32
MDL编号	MFCD12912449
PubChem化学物质编号	329826854

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
溶解性	DMSO: >10 mg/mL H2O: insoluble
储存温度	2-8℃
SMILES string	Cc1ccccc1C#Cc2ccc(CCC(O)=O)cc2
InChI	1S/C18H16O2/c1-14-4-2-3-5-17(14)12-10-15-6-8-16(9-7-15)11-13-18(19)20/h2-9H,11,13H2,1H3,(H,19,20)
InChI key	FODHWOBAQBTTFS-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H319 - H410
预防措施声明	P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391
危险分类	Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves