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TT-10

品牌
Sigma-Aldrich
CAS
2230640-94-3
货号
SML2658
规格纯度
≥98% (HPLC)
价格
1174.92 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
2230640-94-3
TT-10
[4-Amino-2-(2-propen-1-ylamino)-5-thiazolyl](5-fluoro-2-thienyl)methanone
N2-Allyl-5-[(5-fluorothiophen-2-yl)carbonyl]thiazole-2,4-diamine
TT 10
TAZ-K
TAZ K
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

TT-10 (TAZ K) is a TAZ (transcriptional coactivator with PDZ-binding motif) activator that promotes cardiomyocytes (CMs) proliferation (fold-increase by 10 μM TT-10 over untreated control = 5.2/rat CMs/40 hrs & 2.6/human iPSC-derived CMs/48 hrs) by activating YAP (YES-associated protein)/TEAD (transcriptional enhancer factor domain) complex-mediated transcription, as well as by exerting antioxidant and antiapoptotic activity. TT-10 ameliorates myocardial infarction-induced cardiac dysfunction in micein vivo(10 mg/kg i.p.) at least in part via enhancing clonal expansion of existing cardiomyocytes with nuclear YAP expression.

基本信息

经验(实验)分子式 C11H10FN3OS2
分子量 283.35

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 2-8℃
SMILES string NC1=C(C(C2=CC=C(S2)F)=O)SC(NCC=C)=N1

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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