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TM30089

品牌
Sigma-Aldrich
CAS
844639-57-2
货号
SML2743
规格纯度
≥98% (HPLC)
价格
1364.72 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
844639-57-2
TM30089
TM 30089
2-(3-(4-Fluoro-N-methylphenylsulfonamido)-3,4-dihydro-1H-carbazol-9(2H)-yl)acetic acid
CAY 10471
CAY10471
3-[[(4-Fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro-9H-carbazole-9-acetic acid
TM-30089
{3-[(4-Fluorobenzenesulfonyl)methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl}acetic acid
CAY-10471
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

TM30089 is a ramatroban analog and an orally active, high-affinity, potent and selective prostaglandin D2 receptor 2 (DP2; CRTH2) antagonist (Ki = 0.6 nM/hDP2 against 1.2 nM PGD2; Ki = 1.2 μM/hDP1 against 0.5 nM PGD2, >10 μM/hTP against 5 nM SQ29548) that blocks PGD2-induced responses in hDP2 transfectants (IP1/βarr IC50 = 1.2/3.0 nM) and exhibits in vivo efficacy in a murine model of renal tubulointerstitial fibrosis (20 mg/kg b.i.d. p.o., starting 4 days before or 3 days after unilateral ureteral obstruction/UUO).

基本信息

经验(实验)分子式C21H21FN2O4S
分子量416.47
MDL编号MFCD08062186

半岛bd体育手机客户端 性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度−20℃

安全信息

象形图GHS07GHS09
警示用语:Warning
危险声明H315 - H317 - H319 - H410
预防措施声明P273 - P280 - P302 + P352 - P305 + P351 + P338
危险分类Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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