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TFMB-(S)-2HG

品牌
Sigma-Aldrich
CAS
1445703-64-9
货号
SML2563
包装型号
规格纯度
≥98% (HPLC)
价格
1161.11 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
1445703-64-9
TFMB-(S)-2HG
(S)-2-HG-TFMB
(S)-TFMB-OTC
(S)-TFMB-2-HG
(S)-TFMB-2HG
TFMB-(S)-2-HG
(2S)-Tetrahydro-5-oxo-2-furancarboxylic acid, [3-(trifluoromethyl)phenyl]methyl ester
Trifluoromethylbenzyl-(S)-2-HG
(S)-2HG-TFMB
(S)-3-(Trifluoromethyl)benzyl 5-oxotetrahydrofuran-2-carboxylate
TFMB-L2HG
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

TFMB-(S)-2HG is a membrane-permeant (S)-2-hydroxyglutarate (L-2HG) precursor used in conjunction with the oncometabolite (R)-2-hydroxyglutarate (D-2HG) precursor for probing 2-HG enantiomer-specific cellular responses (typical conc used in culture: 0.5-20 mM). While both 2HG enantiomers inhibit multiple α-ketoglutarate (α-KG; 2-OG)-dependent dioxygenases by competing against α-KG binding, (S)-2HG is reported to be more potent against TET1/2, CeKDM7A & KDM5B (JARID1B/PLU-1). On the other hand, (R)-2HG, but not (S)-2HG, is shown to downregulate HIF-1a by promoting EglN1 (HIF prolyl hydroxylase 2; HIF-PH2; PHD2) activity.

基本信息

经验(实验)分子式 C13H11F3O4
分子量 288.22

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 ?20℃

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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