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位置: 首页> 品牌> Sigma-Aldrich> TFLLR-NH2 trifluoroacetate salt

TFLLR-NH2 trifluoroacetate salt

品牌
Sigma-Aldrich
货号
T7830
规格纯度
>98% (HPLC)
价格
1698.93 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
TFLLR-NH2 trifluoroacetate salt
L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl- L-argininamide trifluoroacetate salt
Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

Amino Acid Sequence

Thr-Phe-Leu-Leu-Arg-NH2

应用

TFLLR-NH2trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO).

包装

5, 25 mg in glass bottle

生化/生理作用

TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.

制备说明

TFLLR-NH2 trifluoroacetate is soluble in water at a concentration that is greater than 2 mg/ml.

基本信息

经验(实验)分子式 C31H53N9O6· xC2HF3O2
分子量 647.81 (free base basis)
MDL编号 MFCD05663482
PubChem化学物质编号 329826874
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 >98% (HPLC)
形式 lyophilized powder
颜色 white to tan
溶解性 H2O: >2 mg/mL
储存温度 ?20℃
SMILES string OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
InChI 1S/C31H53N9O6.C2HF3O2/c1-17(2)14-22(27(43)37-21(26(33)42)12-9-13-36-31(34)35)38-28(44)23(15-18(3)4)39-29(45)24(16-20-10-7-6-8-11-20)40-30(46)25(32)19(5)41;3-2(4,5)1(6)7/h6-8,10-11,17-19,21-25,41H,9,12-16,32H2,1-5H3,(H2,33,42)(H,37,43)(H,38,44)(H,39,45)(H,40,46)(H4,34,35,36);(H,6,7)/t19-,21+,22+,23+,24+,25+;/m1./s1
InChI key QVNWOGSDGQDGHP-MKVNCOEFSA-N

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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