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位置: 首页> 品牌> Sigma-Aldrich> N-Acetyl-L-threonyl-L-α-aspartyl-N5-(2-fluoro-1-iminoethyl)-L-ornithinamide trifluoroacetate salt

TDFA trifluoroacetate salt

品牌
Sigma-Aldrich
货号
SML1539
规格纯度
≥98% (HPLC)
价格
3238.33 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
TDFA trifluoroacetate salt
Thr-Asp-F-amidine trifluoroacetate salt
N-Acetyl-L-threonyl-L-α-aspartyl-N5-(2-fluoro-1-iminoethyl)-L-ornithinamide trifluoroacetate salt
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

TDFA trifluoroacetate salt or tripeptide F-amidine analog is a derivative synthesized to increase the selectivity, bioavailability and potency of Cl-amidine, which is a member of protein arginine deiminases (PADs) compounds.

包装

5, 25 mg in glass bottle

生化/生理作用

TDFA (Thr-Asp-F-amidine) is a selective inhibitor of peptidyl arginine deiminase 4 (protein arginine deiminase 4, PAD4 or PADI4), a transcriptional coregulator that catalyzes the calcium-dependent conversion of specific arginine residues in proteins to citrulline, a process called citrullination. PAD4 is upregulated in cancer and inflammatory diseases, and may be involved in rheumatoid arthritis onset and progression. It has recently been found to be involved in the regulation of pluripotency: important for stem-cell gene activation, induced pluripotent stem (iPS) cell reprogramming, and maintenance of pluripotent cells in the early mouse embryo. TDFA has an IC50value of 2.3 μM and is ≥15-fold selective for PAD4 versus PAD1 and ≥50-fold selective versus PADs 2 and 3.

基本信息

经验(实验)分子式 C17H29FN6O7· xC2HF3O2
分子量 448.45 (free base basis)

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
储存条件 desiccated
颜色 white to beige
溶解性 H2O: 10 mg/mL, clear
运输 dry ice
储存温度 ?70℃

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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