Sulindac Sulfide

半岛bd体育手机客户端 说明

应用

Human endothelial cells, HMEC-1 were treated with Sulindac sulfide and the effect on cell survival was studies by MTT assay.

包装

5, 25 mg in glass bottle

生化/生理作用

Sulindac sulfide is a non-steroidal anti-inflammatory compound with a preference for COX-1; it is an inhibitor of Ras activation of Raf-1. It impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. It is an active metabolite of sulindac. It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells and reduces tumor burden in adenomatous polyposis patients.

其他说明

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. S3131.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

基本信息

经验(实验)分子式	C20H17FO2S
分子量	340.41
EC 号	250-892-2
MDL编号	MFCD00869764
PubChem化学物质编号	24899543
NACRES	NA.77

半岛bd体育手机客户端 性质

测定	≥98% (HPLC)
形式	solid
颜色	yellow
溶解性	DMSO: ≥22 mg/mL
SMILES string	[H]\C(c1ccc(SC)cc1)=C2/C(C)=C(CC(O)=O)c3cc(F)ccc23
InChI	1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
InChI key	LFWHFZJPXXOYNR-MFOYZWKCSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H302 - H317 - H334 - H361
预防措施声明	P201 - P280 - P301 + P312 + P330 - P302 + P352 - P308 + P313
危险分类	Acute Tox. 4 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges