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ST034307

品牌
Sigma-Aldrich
CAS
133406-29-8
货号
SML2109
规格纯度
≥98% (HPLC)
价格
1023.54 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
133406-29-8
ST034307
6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
6-Chloro-2-(trichloromethyl)chromen-4-one
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

ST034307 is a selective inhibitor of adenylyl cyclase 1 (AC1) with analgesic activity. Adenylyl cyclase 1 has been shown to be a potential target for treating pain and reducing the dependency on opioids, but it has been difficult to inhibit AC1 selectively without also inhibiting other isoforms vital to physiological functions. ST034307 is selective for AC1 over all eight other adenylyl cyclase isoforms. It inhibited AC1 and reduced cAMP, while leaving AC8 unaffected and was shown to reduce pain in a mouse inflammatory pain model.

基本信息

经验(实验)分子式 C10H4Cl4O2
分子量 297.95
MDL编号 MFCD00760793
NACRES NA.77

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 powder
颜色 faint green to dark gray
溶解性 DMSO: 2 mg/mL, clear (warmed)
储存温度 ?20℃
SMILES string ClC(Cl)(Cl)C1=CC(C2=CC(Cl)=CC=C2O1)=O

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3

Sigma-Aldrich

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