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SR 142948A

品牌
Sigma-Aldrich
CAS
184162-21-8
货号
SML0015
规格纯度
≥98% (HPLC)
价格
2280.72 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
184162-21-8
SR 142948A
SR 142948 hydrochloride
2-[[5-(2,6-dimethoxyphenyl)-1-(4-(N-(3-dimethylaminopropyl)-N-methylcarbamoyl)-2-isopropylphenyl)-1H-pyrazole3-carbonyl]amino] adamantane-2-carboxylic acid hydrochloride
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

SR 142948A was used to study the role of neurotensin signaling in intracellular alkanization and expression of IL-8 in human pancreatic cancer cells.

包装

5, 25 mg in glass bottle

生化/生理作用

SR 142948A is a non-peptide Neurotensin receptor antagonist
SR 142948A is a potent neurotensin receptor antagonist that affects the expression of c-Fos and has properties of antipsychotic agent. It blocks hypothermia and analgesia induced by neurotensin. It blocks the increase in the concentration of Ca+2induced by the activation of phospholipase C in CHO cell model.

特点和优势

This compound is featured on the Neurotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式 C39H51N5O6·HCl
分子量 722.31
MDL编号 MFCD03106502
PubChem化学物质编号 329825090
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 H2O: ≥2 mg/mL at warmed to 60 ℃
创始人 Sanofi Aventis
储存温度 2-8℃
SMILES string Cl.COc1cccc(OC)c1-c2cc(nn2-c3ccc(cc3C(C)C)C(=O)N(C)CCCN(C)C)C(=O)NC4([C@@H]5C[C@H]6C[C@@H](C5)C[C@@H]4C6)C(O)=O
InChI 1S/C39H51N5O6.ClH/c1-23(2)29-21-26(37(46)43(5)15-9-14-42(3)4)12-13-31(29)44-32(35-33(49-6)10-8-11-34(35)50-7)22-30(41-44)36(45)40-39(38(47)48)27-17-24-16-25(19-27)20-28(39)18-24;/h8,10-13,21-25,27-28H,9,14-20H2,1-7H3,(H,40,45)(H,47,48);1H/t24-,25+,27-,28+,39?;
InChI key CUYNEHGBVHUQQW-BVJGGMLGSA-N

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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