sphinganine (d17:0)

半岛bd体育手机客户端 说明

一般描述

Sphinganine (d17:0), also referred to as dihydrosphingosine, is devoid of double bond. Decarboxylating condensation of serine with palmitoyl-CoA yield keto intermediate(2-oxosphinganine), which is then reduced by NADPH to form Sphinganine.

应用

Sphinganine (d17:0) has been used in liquid chromatography-mass spectrometry (LC-MS) for thein-situestimation of dihydrosphingosine utilization in N-(4-hydroxyphenyl)retinamide (4-HPR) resistant leukemia cells. It is suitable for use as an internal standard in metabolomic study.

生化/生理作用

Sphinganine (SPA) or D-erythro-sphinganine is involved in sphingolipid biosynthesis pathway. It acts as a precursor for ceramide. SPA has an ability to inhibit the activity of protein kinase c. SPA accumulation enables fumonisin B1 to stimulate apoptosis. It also has an ability to block cholesterol transport in Niemann-Pick Type C (NPC) disease.

包装

5 mL Amber Glass Screw Cap Vial (860654P-5mg)
5 mL Amber Glass Screw Cap Vial (860654P-10mg)

基本信息

经验(实验)分子式	C17H37NO2
分子量	287.48
NACRES	NA.25

半岛bd体育手机客户端 性质

形式	powder
包装	pkg of 1 × 10 mg (860654P-10mg) pkg of 1 × 5 mg (860654P-5mg)
manufacturer/tradename	Avanti Polar Lipids 860654P
运输	dry ice
储存温度	?20℃
SMILES string	OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCC

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3