SKA-31

半岛bd体育手机客户端 说明

包装

5, 25 mg in glass bottle

生化/生理作用

SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC₅₀is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension.

基本信息

经验(实验)分子式	C11H8N2S
分子量	200.26
MDL编号	MFCD00051329
PubChem化学物质编号	329824457

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
溶解性	DMSO: ≥30 mg/mL
储存温度	?20℃
SMILES string	Nc1nc2c(ccc3ccccc23)s1
InChI	1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
InChI key	FECQXVPRUCCUIL-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H319
预防措施声明	P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码	11 - Combustible Solids
闪点(F)	Not applicable
闪点(C)	Not applicable