半岛bd体育手机客户端 说明
生化/生理作用
Sitafloxacin (DU-6859 or DU-6859a) is an orally active, fourth generation fluoroquinolone that exhibits broad-spectrum antibiotic activity against many Gram-positive, Gram-negative and anaerobic clinical isolates, including strains resistant to other fluoroquinolones, via dual inhibitory activity against bacterial DNA gyrase and topoisomerase IV (IC50= 1.16 and 1.88 μg/mL againstS. pneumoniaegyrA/B and parC/E, respectively). Sitafloxacin is active against methicillin-resistant staphylococci,Streptococcus pneumoniaeand other streptococci with reduced susceptibility to levofloxacin and other quinolones and enterococci. Sitafloxacin also exhibits activity against clinical isolates ofKlebsiella pneumoniae,Enterobacter cloacae,Pseudomonas aeruginosaas well as some activity against quinolone-resistant strains andAcinetobacter baumannii. Sitafloxacinin vitroactivity against anaerobes is comparable to imipenem and metronidazole.
基本信息
| 经验(实验)分子式 | C19H18ClF2N3O3·1.5H2O |
| 分子量 | 436.84 |
| MDL编号 | MFCD00903720 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 储存条件 | desiccated |
| 颜色 | white to beige |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
