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位置: 首页> 品牌> Sigma-Aldrich> 5′-S-[4-[(4′-Chlorobiphenyl-3-ylmethyl)amino]butyl]-5′-thioadenosine

SGC8158

5′-S-[4-[(4′-Chlorobiphenyl-3-ylmethyl)amino]butyl]-5′-thioadenosine

品牌
Sigma-Aldrich
货号
SML2340
规格纯度
≥98% (HPLC)
价格
2097.27 *本价格含增值税费
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半岛bd体育手机客户端 名称:
SGC8158
5′-S-[4-[(4′-Chlorobiphenyl-3-ylmethyl)amino]butyl]-5′-thioadenosine
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

SGC8158 isthe active component produced by cell reductases from the prodrug, SGC3027, a selective and cell-active inhibitor of protein arginine N-methyltransferase (PRMT7). SGC8158 was shown to inhibit PRMT7 with an IC50 value < 2.5 nM for methylation of H2B (23-37) and greater than 40-fold selectivity over other histone methyltransferases and non-epigenetic targets. SGC3027 inhibited the methylation of HSP70 In cellular assays using C2C12 cells with an IC50 value of 1.3 microM. The closely related SGC3027N is significantly less active in the cellular assay, and is a control compound for cellular studies.

基本信息

经验(实验)分子式 C27H31ClN6O3S
分子量 555.09

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 2-8℃
SMILES string ClC(C=C1)=CC=C1C2=CC(CNCCCCSC[C@H]3O[C@@H](N(C=N4)C5=C4C(N)=NC=N5)[C@H](O)[C@@H]3O)=CC=C2

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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