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位置: 首页> 品牌> Sigma-Aldrich> 4-fluoro-α-(4-fluorophenyl)-α-phenyl-Benzeneacetamide

Senicapoc

4-fluoro-α-(4-fluorophenyl)-α-phenyl-Benzeneacetamide

品牌
Sigma-Aldrich
CAS
289656-45-7
货号
SML2500
规格纯度
≥98% (HPLC)
价格
817.68 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
289656-45-7
Senicapoc
ICA 17043
4-fluoro-α-(4-fluorophenyl)-α-phenyl-Benzeneacetamide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Senicapoc (ICA-17043) is an inhibitor of the calcium-activated K+channel KCa3.1, also known as the Gardos channel, which plays a role in K+loss and dehydration of sickled red blood cells. Senicapoc blocks calcium-induced rubidium flux in human RBCs with and IC50 of 11 nM and prevents RBC dehydration in a transgenic mouse sickle cell disease model. It has been investigated for a number of possible uses, which include antimalarial activity, idiopathic pulmonary fibrosis, glioblastoma, lung cancer, non-alcoholic liver disease, hereditary xerocytosis, suppression of microglial activation in stroke, and immune system disorders.

基本信息

经验(实验)分子式 C20H15F2NO
分子量 323.34
MDL编号 MFCD09027349

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 2-8℃
SMILES string O=C(N)C(C1=CC=C(F)C=C1)(C2=CC=C(F)C=C2)C3=CC=CC=C3
InChI 1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
InChI key SCTZUZTYRMOMKT-UHFFFAOYSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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