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SB-277011-A hydrochloride hydrate

品牌
Sigma-Aldrich
CAS
215804-67-4
货号
S4326
规格纯度
≥98% (HPLC)
价格
1642.3 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
215804-67-4
SB-277011-A hydrochloride hydrate
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

SB-277011-A hydrochloride hydrate has been used:

  • as a dopamine D3 receptor-selective antagonist in rats to test its effect on 4-propyl-9-hydroxynaphthoxazine ([3H]-(+)-PHNO) radiotracer in cerebellum L9/10 and striatum
  • as an acetylcholine inhibitor to test its negative allosteric modulation onAscaris suumnicotinic acetylcholine receptor (Asu-ACR-16) expressed inXenopusoocytes and its inhibitory effect on locomotion inCaenorhabditis elegans
  • to test its effect on alcohol consumption in mice


SB-277011-A hydrochloride hydrate may be used in D3 dopamine receptor-mediated cell signaling studies.

包装

5, 25 mg in glass bottle

生化/生理作用

The D3dopamine receptor antagonist, SB-277011-A inhibits the cocaine-seeking behavior and cocaine-enhances brain stimulation reward in in rats. It decreases drug-seeking behavior and may be useful in treatment of cocaine and methamphetamine addiction.
SB-277011-A is a potent, selective brain-penetrant D3 dopamine receptor antagonist; 80-100x selective for D3 over D2; pKi = 7.95 for hD3 receptor.

特点和优势

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式 C28H30N4O · HCl · xH2O
分子量 475.02 (anhydrous basis)
MDL编号 MFCD16875431
PubChem化学物质编号 329824542

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
储存条件 protect from light
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear (warmed)
创始人 GlaxoSmithKline
储存温度 2-8℃
SMILES string O.Cl.O=C(N[C@@H]1CC[C@H](CC1)CCN2CCc3cc(ccc3C2)C#N)c4ccnc5ccccc45
InChI 1S/C28H30N4O.ClH.H2O/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27;;/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33);1H;1H2/t20-,24-;;
InChI key OOWNBQACGIKNGM-ONAIBGCWSA-N

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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