S1QEL1.1

品牌

Sigma-Aldrich

CAS

897613-29-5

货号

SML1948

包装型号

规格纯度

≥98% (HPLC)

价格

1570.76 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

897613-29-5
S1QEL1.1
N1-(3-acetamidophenyl)-N2-(2-(4-methyl-2-(p-tolyl)thiazol-5-yl)ethyl)oxalamide
S1QEL

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

应用

S1QEL1.1 has been used as a reverse electron transport (RET)-induced mitochondrial (mito) reactive oxygen species (ROS) suppressor:

to investigate the role of mitochondrial-derived superoxide in triggering ferroptosis
to study the mechanism involved in the regulation of anti-fungal responses of macrophages againstAspergillusinfection
in combination with mito-antioxidant to study their influence on mitochondria-derived H₂O₂in cancer cells
to determine the effect of oxidative stress depletion on myoblast differentiation

生化/生理作用

S1QEL1.1 is a suppressor of mitochondrial respiratory complex I site IQ electron leak, suppressing superoxide and/or H₂O₂production without altering oxidative phosphorylation. S1QEL1.1 had an IC50 values of 70 nM against superoxide-H₂O₂production from site IQ. It decreased caspase activation in a in a cardiomyocyte cell model of ER stress and decreased ischemia-reperfusion injury in the Langendorff-perfused mouse heart model.
Suppressors of the site IQ electron leak (S1QEL)1.1 reduces cytokine secretion and fungicidal activity of macrophages infected with swollenA. fumigatusconidia by suppressing reverse electron transport (RET)-induced mitochondrial reactive oxygen species (ROS).

基本信息

经验(实验)分子式	C₂₃H₂₄N₄O₃S
分子量	436.53

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
运输	wet ice
储存温度	?20℃
SMILES string	CC1=C(CCNC(C(NC2=CC=CC(NC(C)=O)=C2)=O)=O)SC(C3=CC=C(C)C=C3)=N1

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable