您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> S 38093-2

S 38093-2

品牌
Sigma-Aldrich
CAS
1403835-46-0
货号
SML2177
规格纯度
≥98% (HPLC)
价格
1048.99 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
1403835-46-0
S 38093-2
4-(3-((3aR,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy)benzamide hydrochloride
S 38093
S-38093
S38093
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

S 38093 is an orally available compound with selective affinity toward histamine H3 receptor (human/mouse/rat H3R Ki = 0.2/1.44/8.8 μM), but not other histaminergic receptors, exhbiting both antagonist (KB = 652 nM against 300 nM (R)-α-Methylhistamine-induced GTPγS recruitment to mH3 CHO membrane; KB = 110 nM against 1 μM histamine-induced cAMP downregulation in hH3 CHO cells) and inverse agonist activity (hH3/rH3 HEK basal cAMP enhancing EC50 = 1.7/9 μM; 48% inhibition of ionomycin-induced hH3 or rH3 HEK AA reslease by 10 μM S 38093). S 38093 is reported to improve AD- and age-associated memory and cognition deficits in mice (0.1-3 mg/kg/day p.o.) and rats (0.1-10 mg/kg p.o. or i;p.), as well as display antiallodynic and antihyperalgesic efficacy in rat models of neuropathic painin vivo.

基本信息

经验(实验)分子式 C17H24N2O2· HCl
分子量 324.85
NACRES NA.77

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 powder
储存条件 desiccated
颜色 white to beige
溶解性 H2O: 2 mg/mL, clear
储存温度 2-8℃
SMILES string [H][C@@]([C@]1([H])C2)(CCC1)CN2CCCOC3=CC=C(C(N)=O)C=C3.Cl

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map