半岛bd体育手机客户端 说明
生化/生理作用
PF-915275 is an orally active, potent and selective 11beta-hydroxysteroid dehydrogenase type 1 (11?-HSD1, HSD11B1) inhibitor (human 11?-HSD1 Ki <1 nM; cellular IC50= 5 nM using human 11?-HSD1-transfected HEK293) with reduced potency toward non-human species (human/monkey/dog hepatocytes EC50= 20/100/120 nM; mouse 11?-HSD1 Ki = 750 nM, rat hepatoma EC50 = 14 μM). PF-915275 (0.1-3-mg/kg via nasogastric intubations) inhibits prednisone-to-prednisolone conversion in cynomolgus monkeys (by 87% with 3 mg/kg)in vivoand reduces plasma insulin increase following prednisone & resumed feeding (4 hrs post PF-915275) among overnight fasted monkeys.
法律信息
Sold for research purposes under agreement from Pfizer Inc.
基本信息
| 经验(实验)分子式 | C18H14N4O2S |
| 分子量 | 350.39 |
| MDL编号 | MFCD12828758 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 储存温度 | room temp |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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