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PF-06815345

品牌
Sigma-Aldrich
CAS
2334434-49-8
货号
PZ0406
规格纯度
≥98% (HPLC)
价格
833.87 *本价格含增值税费
促销
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半岛bd体育手机客户端 名称:
2334434-49-8
PF-06815345
(1S)-1-(5-(4-(4-((3-Chloropyridin-2-yl)((R)-piperidin-3-yl)carbamoyl)-2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)-1H-tetrazol-1-yl)ethyl ethyl carbonate hydrochloride
PF 06815345
PF06815345
Ethyl (S)-1-{5-[4-(4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}-2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-1H-tetrazol-1-yl}ethyl carbonate hydrochloride
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

PF-06815345 is a liver-targeted, orally available prodrug, which is converted by liver carboxyesterase (CES1) to its zwitterionic active drug (liver active drug = 33.9 μg/mL in mice 0.5 hr post 300 mg/kg p.o. and 9.0 μg/mL in monkeys 0.5 hr post 30 mg/kg p.o.) that selectively inhibits PCSK9 protein synthesis (IC50= 3.7 μM byin vitrohPCSK9 translation; 4.95/3.81/21/24/>27-fold selective over CDH1/HSD17B11/PCBP2/RPL27/BCAP31). PF-06815345 effectively lowers plasma PCSK9 in humanized PCSK9 mice (by 26/42/53% 5 hrs post 100/300/500 mg/kg p.o.) and is well tolerated in rats and monkeysin vivo. Note: PF-06815345 is not active in non-humanized mice.

法律信息

Sold for research purposes under agreement from Pfizer Inc.

基本信息

经验(实验)分子式 C27H29ClFN9O4·HCl
分子量 634.49

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
旋光性 [α]/D -34 to -43°, c = 0.3 in methanol
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 room temp

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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