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PD168393

品牌
Sigma-Aldrich
CAS
194423-15-9
货号
PZ0285
规格纯度
≥98% (HPLC)
价格
1106.81 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
194423-15-9
PD168393
4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-propenamide
PD 168393
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

PD168393 has been used in the acute inhibition of ErbB4.

包装

5, 25 mg in glass bottle

生化/生理作用

PD168393 is a 6-acrylamido-4-anilinoquinazoline compound. It increases apoptosis in malignant peripheral nerve sheath tumor cells, stimulated by lysosomal dysfunction.
PD168393 is potent, cell-permeable, irreversible and selective inhibitor of EGF receptor (EGFR) tyrosine kinase and ErbB2. PD168393 has an IC50value of 0.70 nM for EGFR, and is inactive against insulin, PDGFR, FGFR and PKC.

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式 C17H13BrN4O
分子量 369.22
MDL编号 MFCD02179207
PubChem化学物质编号 329823812
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
manufacturer/tradename Pfizer?
颜色 white to beige
溶解性 DMSO: 25 mg/mL, clear
创始人 Pfizer
储存温度 room temp
SMILES string C=CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O
InChI 1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)
InChI key HTUBKQUPEREOGA-UHFFFAOYSA-N

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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