PaPE-1

半岛bd体育手机客户端 说明

包装

5, 25 mg in glass bottle

生化/生理作用

PaPE-1 is a "Pathway Preferential Estrogen" that activates the extranuclear signaling pathway without activating the nuclear signaling pathway. PaPE-1 bound 50,000-fold less well to ERα and Erβ estrogen receptors. PaPE-1 activated extranuclear-initiated ER-regulated genes, but showed essentially no activation of nuclear-initiated estrogen receptor (ER) gene targets such as the progesterone receptor. Unlike estradiol (E2), PaPE-1 did not stimulate proliferation of MCF-7 breast cancer cells. Like estradiol, PaPE-1 strongly activated MAPK and mTOR pathway. Instead, it showed preferential estrogen-like activity in non-reproductive (metabolic and vascular) tissues, reducing body weight gain and fat accumulation in ovariectomized mice and accelerating repair of endothelial damage in the vascualture.

基本信息

经验(实验)分子式	C17H18O2
分子量	254.32
MDL编号	MFCD30723184

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 25 mg/mL, clear
储存温度	2-8℃
SMILES string	O[C@H]1CCC2=C1C=CC(C3=CC(C)=C(O)C(C)=C3)=C2

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319
预防措施声明	P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3