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PAC-1

品牌
Sigma-Aldrich
CAS
315183-21-2
货号
P0115
规格纯度
≥98% (HPLC)
价格
1353.36 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
315183-21-2
PAC-1
1-Piperazineacetic acid, 2-(phenylmethyl)-,[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hyrrazide
(4-Benzylpiperazino)acetic acid (3-allyl-2-hyroxybenzylidene)hydrazide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Procaspase-activating compound 1 (PAC-1) is an ortho-hydroxy N-acyl hydrazine compound. It is cytotoxic to a variety of cancer cells, such as lymphoma, leukaemia, breast carcinoma and glioblastoma. High doses of PAC-1 can promote neuroexcitation. It helps in the in vitro autoactivation of the proenzyme protease, which acts as a prototype for other protease activating compounds. PAC-1 dependant activation of procaspase-3 is associated with the chelation of zinc.

包装

5, 25 mg in glass bottle

生化/生理作用

PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.

特点和优势

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式 C23H28N4O2
分子量 392.49
MDL编号 MFCD03302441
PubChem化学物质编号 329820019
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
颜色 white
溶解性 DMSO: ≥10 mg/mL
deionized water: ≤2 mg/mL
储存温度 room temp
SMILES string Oc1c(CC=C)cccc1\C=N\NC(=O)CN2CCN(CC2)Cc3ccccc3
InChI 1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,29H,1,7,12-15,17-18H2,(H,25,28)/b24-16+
InChI key YQNRVGJCPCNMKT-LFVJCYFKSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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