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位置: 首页> 品牌> Sigma-Aldrich> Ombrabulin hydrochloride

Ombrabulin hydrochloride

品牌
Sigma-Aldrich
CAS
253426-24-3
货号
SML1549
包装型号
规格纯度
≥98% (HPLC)
价格
4498.97 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
253426-24-3
Ombrabulin hydrochloride
Ombrabulin HCl
AVE 8062A
AC 7700
(2S)-2-Amino-3-hydroxy-N-[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]-propanamide hydrochloride
AVE8062
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Ombrabulin is a member of the combretastatin A-4 compound class and is a tubulin-depolymerising tumour vascular-disrupting compound.

包装

5, 25 mg in glass bottle

生化/生理作用

Ombrabulin is a synthetic water-soluble combretastatin analog vascular disrupting agent. Ombrabulin is a tubulin polymerization inhibitor. Ombrabulin binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells.
Ombrabulin leads to the constriction of the arteries, inhibits cell proliferation and causes detachment of endothelial cells, thereby leading to cytotoxicity. In pre-clinical studies, this compound, along with cisplatin, has shown anti-tumor activity. In tumors, it is responsible for the destruction of the vasculature.

基本信息

经验(实验)分子式 C21H26N2O6· HCl
分子量 438.90
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
储存条件 desiccated
颜色 white to beige
溶解性 H2O: 20 mg/mL, clear
储存温度 2-8℃

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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