半岛bd体育手机客户端 说明
生化/生理作用
Compound 8 (C8) is a small molecule that directly targets TRPM4 TwinF domain and blocks its interaction with GluN2A/GluN2B (NR2A/NR2B) I4 domain. C8 prevents NMDAR/TRPM4 interaction-dependent excitotoxicity (death protection EC50 = 2.1 μM 24 h post 10-min exposure of primary murine hippocampal neurons to 20 μM NMDA) without affecting, and even enhancing, NMDAR-mediated essential functions. C8 protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell (RGC) loss in micein vivo(40 mg/kg i.p. at -16h, -3h before, 0h, 3h, 24h after MCAO or 20 nmol NMDA/2.0 μL by intravitreal injection).
基本信息
| 经验(实验)分子式 | C11H17BrN2·2HCl |
| 分子量 | 330.09 |
| MDL编号 | MFCD31668685 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder or solid |
| 储存条件 | desiccated |
| 颜色 | white to beige |
| 溶解性 | H2O: 2 mg/mL, clear |
| 储存温度 | ?20℃ |
| SMILES string | NCCN(CC)CC1=CC=CC(Br)=C1.Cl.Cl |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
