半岛bd体育手机客户端 说明
一般描述
N2-Et-dG, an adduct between DNA and the first metabolite of ethanol (acetaldehyde), strongly blocks transcription by RNA polymerases (RNAPs), including mammalian RNAPII and yeast RNAPII,E. coliRNAP, as well as T7 RNAP. All three of the multisubunit RNAPs incorporate a single rNTP residue opposite the N2-Et-dG lesion. The mammalian RNAPII exclusively incorporates cytidine monophosphate (CMP) opposite the N2-Et-dG lesion. The accessory transcription factor TFIIS does not usually act as a lesion bypass factor; instead, it stimulates the polymerase to remove the CMP incorporated opposite the lesion by mammalian RNAPII. N2-Et-dG reduces CTP incorporation by ~1500 fold.
包装
5, 25 mg in glass bottle
基本信息
| 经验(实验)分子式 | C12H17N5O4 |
| 分子量 | 295.29 |
| MDL编号 | MFCD01631004 |
| PubChem化学物质编号 | 329818605 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 颜色 | white to off-white |
| 溶解性 | H2O: >5 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | CCNC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](CO)O3)C(=O)N1 |
| InChI | 1S/C12H17N5O4/c1-2-13-12-15-10-9(11(20)16-12)14-5-17(10)8-3-6(19)7(4-18)21-8/h5-8,18-19H,2-4H2,1H3,(H2,13,15,16,20)/t6-,7+,8+/m0/s1 |
| InChI key | VOKQFDULHQUWAV-XLPZGREQSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H300 + H310 + H330 - H351 - H373 |
| 预防措施声明 | P201 - P202 - P260 - P280 - P302 + P352 + P310 - P304 + P340 + P310 |
| 危险分类 | Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Carc. 2 - STOT RE 2 |
| 储存分类代码 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
Sigma-Aldrich
m.cnreagent.com
