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MDL-800

品牌
Sigma-Aldrich
CAS
2275619-53-7
货号
SML2529
规格纯度
≥98% (HPLC)
价格
1453.88 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
2275619-53-7
MDL-800
Methyl 2-(N-(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-(3,5-dichlorophenylsulfonamido)benzoate
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

MDL-800 is a selective allosteric activator of SIRT6, a member of the SIRT deacetylase family that is responsible for deacetylation of histones H3K9Ac and H3K56ac and has tumor suppressor activity. MDL-800 increased the deacetylase activity of SIRT6 by up to 22-fold resulting in a decrease in H3K9Ac and H3K56Ac in hepatocellular carcinoma (HCC) cells, causing cell cycle arrest and inhibiting their proliferation. It also suppressed the growth of xenografts of the hepatocellular carcinoma cell line BEL7405.

基本信息

经验(实验)分子式 C21H16BrCl2FN2O6S2
分子量 626.30
MDL编号 MFCD31813709

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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