L48H37 - 半岛电竞官方网址

L48H37

品牌

Sigma-Aldrich

货号

SML1443

包装型号

规格纯度

≥98% (HPLC)

价格

1117.23 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

L48H37
1-Ethyl-3,5-bis[(2,3,4-trimethoxyphenyl)methylene]-4-piperidinone
(3E,5E)-1-ethyl-3,5-bis[(2,3,4-trimethoxyphenyl)methylidene]piperidin-4-one
1-Ethyl-3,5-bis(3,4,5-trimethoxybenzylidene)piperidin-4-one

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

应用

L48H37 has been used as a myeloid differentiator protein 2 (MD2) antagonist/inhibitor:

to investigate intracellular signaling of LPS in signal transduction pathways via endosomic toll-like receptor 4 (TLR4) in colonic epithelium
to determine its anti-cancer effects in pancreatic ductal adenocarcinoma (PDAC)
to study its effects on lipopolysaccharide (LPS) and palmitate CC chemokine ligand 2 (CCL2) responses in normal kidney proximal tubule cells

包装

5, 25 mg in glass bottle

生化/生理作用

L48H37 can stimulate apoptosis and prevent proliferation in pancreatic cancer cells, especially in the absence of histone-lysine N-methyltransferase 2D (KMT2D). It has an unsaturated monoketone structure, which helps to enhance its stability and anti-cancer effects. L48H37 may possess an anti-neoplastic effect on human pancreatic ductal adenocarcinoma (PDAC) cells.
L48H37 is a potent and chemically stable anti-inflammatory curcumin analog that inhibits LPS-induced inflammation through the myeloid differentiation 2 (MD-2) and toll-like receptor 4 (TLR4) complex. L48H37 is a potent MD2 inhibitor that binds to the hydrophobic region of MD-2 and blocks the interaction between MD2 and LPS. L48H37 significantly improves survival and protected lung injury in LPS-induced septic mice.

基本信息

经验(实验)分子式	C₂₇H₃₃NO₇
分子量	483.55
PubChem化学物质编号	329825883
NACRES	NA.77

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	O=C(/C(CN(CC)C/1)=C/C2=C(OC)C(OC)=C(OC)C=C2)C1=C\C3=CC=C(OC)C(OC)=C3OC
InChI	1S/C27H33NO7/c1-8-28-15-19(13-17-9-11-21(30-2)26(34-6)24(17)32-4)23(29)20(16-28)14-18-10-12-22(31-3)27(35-7)25(18)33-5/h9-14H,8,15-16H2,1-7H3/b19-13+,20-14+
InChI key	XLPNFINERWLGNC-IWGRKNQJSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable