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JW55

品牌
Sigma-Aldrich
CAS
664993-53-7
货号
SML0630
包装型号
规格纯度
≥98% (HPLC)
价格
1129.94 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
664993-53-7
JW55
N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

JW55 has been used as a tankyrase-specific inhibitor to study its effects on the transcriptional activity of SRY-related HMG-box gene 9 (Sox9) in chondrocytes.

包装

5, 25 mg in glass bottle

生化/生理作用

JW55 is a potent and selective inhibitor of Wnt/β-catenin signaling, that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2) leading to stabilization of AXIN2 followed by increased degradation of β-catenin. JW55 specifically inhibits canonical Wnt signaling that results in reduced cell-cycle progression, proliferation, and colony formation in colon carcinoma cell lines.
JW55 can decrease the formation of mouse colon adenomain vivo.It possesses a methoxyphenyl moiety spreading towards the G-loop.

其他说明

JW55 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the JW55 probe summary on the Chemical Probes Portal website.

基本信息

经验(实验)分子式 C25H26N2O5
分子量 434.48
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 15 mg/mL, clear
储存温度 2-8℃

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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