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位置: 首页> 品牌> Sigma-Aldrich> 2-(3′-Fluoro-5′-(1-(2-(methylamino)-2-oxoethyl)-1H-pyrazol-4-yl)-2,5-dioxo-2′,3′-dihydrospiro[imidazolidine-4,1′-indene]-1-yl)-N-(4-fluorobenzyl)-N-(1,1,1-trifluoropropan-2-yl)acetamide

iP300

2-(3′-Fluoro-5′-(1-(2-(methylamino)-2-oxoethyl)-1H-pyrazol-4-yl)-2,5-dioxo-2′,3′-dihydrospiro[imidazolidine-4,1′-indene]-1-yl)-N-(4-fluorobenzyl)-N-(1,1,1-trifluoropropan-2-yl)acetamide

品牌
Sigma-Aldrich
CAS
2624336-90-7
货号
SML3042
规格纯度
≥97% (HPLC)
价格
2856.67 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
2624336-90-7
iP300
iP300w and iP300v mix
iP300v/w
iP300w/v
N-(4-fluorobenzyl)-2-(3-fluoro-5-{1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl}-2,5-dioxo-2,3-dihydro-1H-spiro[imidazolidine-4,1-inden]-1-yl)-N-(1,1,1-trifluoropropan-2-yl)acetamide
2-(3′-Fluoro-5′-(1-(2-(methylamino)-2-oxoethyl)-1H-pyrazol-4-yl)-2,5-dioxo-2′,3′-dihydrospiro[imidazolidine-4,1′-indene]-1-yl)-N-(4-fluorobenzyl)-N-(1,1,1-trifluoropropan-2-yl)acetamide
3-Fluoro-N-[(4-fluorophenyl)methyl]-2,3-dihydro-5-[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-(2,2,2-trifluoro-1-methylethyl)spiro[imidazolidine-4,1-[1H]indene]-1-acetamide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

iP300, a mixture of 8 diastereomers, is a potent histone acetyltransferase (HAT) p300/CBP inhibitor (p300 IC50 = 33 nM by H3K9Ac HTRF assay). An active diastereomer(s)-enriched pool (iP300w) obtained by partial HPLC separation prevents DUX4-induced cytotoxicity and transcription activity in human myoblast LHCN-M2 cultures (0.1-1 μM) and shows in vivo efficacy against muscle loss (0.3 mg/kg/day i.p.) in a murine model of facioscapulohumeral muscular dystrophy (FSHD).

基本信息

经验(实验)分子式 C29H27F5N6O4
分子量 618.55

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥97% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 ?20℃
SMILES string O=C(NC1(C2=O)CC(C3=C1C=CC(C4=CN(N=C4)CC(NC)=O)=C3)F)N2CC(N(CC5=CC=C(C=C5)F)C(C(F)(F)F)C)=O

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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