半岛bd体育手机客户端 说明
生化/生理作用
iP300, a mixture of 8 diastereomers, is a potent histone acetyltransferase (HAT) p300/CBP inhibitor (p300 IC50 = 33 nM by H3K9Ac HTRF assay). An active diastereomer(s)-enriched pool (iP300w) obtained by partial HPLC separation prevents DUX4-induced cytotoxicity and transcription activity in human myoblast LHCN-M2 cultures (0.1-1 μM) and shows in vivo efficacy against muscle loss (0.3 mg/kg/day i.p.) in a murine model of facioscapulohumeral muscular dystrophy (FSHD).
基本信息
经验(实验)分子式 | C29H27F5N6O4 |
分子量 | 618.55 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥97% (HPLC) |
形式 | powder |
颜色 | white to beige |
溶解性 | DMSO: 2 mg/mL, clear |
储存温度 | ?20℃ |
SMILES string | O=C(NC1(C2=O)CC(C3=C1C=CC(C4=CN(N=C4)CC(NC)=O)=C3)F)N2CC(N(CC5=CC=C(C=C5)F)C(C(F)(F)F)C)=O |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich