半岛bd体育手机客户端 说明
包装
5, 25 mg in glass bottle
生化/生理作用
IMB5046 is a microtubule inhibitor that has antitumor activity, overcoming multidrug-resistance. IMB5046 was cytotoxic with an IC50range of 37 to 426 nM against multiple tumor cell lines, including some that were resistant to colchicine, vincristine and paclitaxel. IMB5046 was also active against human lung tumor xenografts. IMB5046 was found to bind to tubulin at the colchicine site, but with a different binding mode. IMB5046 inhibited tubulin polymerization, and induced G2/M arrest.
基本信息
| 经验(实验)分子式 | C19H20N2O5S |
| 分子量 | 388.44 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 20 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | O=C(C1=C(N2CCOCC2)C=CC([N+]([O-])=O)=C1)OCC3=CC=C(SC)C=C3 |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
