IBR2 - 半岛电竞官方网址

IBR2

品牌

Sigma-Aldrich

CAS

952739-54-7

货号

SML2257

包装型号

规格纯度

≥98% (HPLC)

价格

1154.09 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

952739-54-7
IBR2
(R)-2-(benzylsulfonyl)-1-(1H-indol-3-yl)-1,2-dihydroisoquinoline
Isoquinoline, 1,2-dihydro-1-(1H-indol-3-yl)-2-[(phenylmethyl)sulfonyl]-, (1R)-
(1R)-1,2-Dihydro-1-(1H-indol-3-yl)-2-[(phenylmethyl)sulfonyl]isoquinoline

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

生化/生理作用

IBR2 is a cell penetrant, potent and specific RAD51 inhibitor that inhibits RAD51-mediated DNA double-strand break repair and enhances cytotoxicity of multiple anticancer agents with disparate biochemical targets including the Bcr-Abl inhibitor imatinib and multiple kinase inhibitor regorafenib. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, reduces ionizing radiation-induced RAD51 foci formation, inhibits cancer cell growth and induces apoptosis.

基本信息

经验(实验)分子式	C₂₄H₂₀N₂O₂S
分子量	400.49
NACRES	NA.77

半岛bd体育手机客户端性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=S(N1[C@@H](C2=CNC3=C2C=CC=C3)C4=CC=CC=C4C=C1)(CC5=CC=CC=C5)=O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable