EN219 - 半岛电竞官方网址

半岛bd体育手机客户端名称：

380351-29-1
EN219
1-(3,5-bis(4-Bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-chloroethanone
3,5-bis(4-Bromophenyl)-1-(chloroacetyl)-4,5-dihydro-1H-pyrazole

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

生化/生理作用

EN219 is a cell-permeable chloroacetamide compound that selectively inhibits E3 ligase RNF114-mediated autoubiquitination and p21 ubiquitination. EN219 is shown to covalently interact with RNF114-C8 (IC50 = 470 nM), TUBB1-C201, HSPD1-C442, and HIST1H3A-C97. EN219 is a recruiter of the E3 ubiquitin ligase RNF114 that can be utilized for PROTAC applications.

基本信息

经验(实验)分子式	C₁₇H₁₃Br₂ClN₂O
分子量	456.56
MDL编号	MFCD02989881

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable