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Dynarrestin

品牌
Sigma-Aldrich
CAS
2222768-84-3
货号
SML2332
规格纯度
≥98% (HPLC)
价格
1045.52 *本价格含增值税费
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半岛bd体育手机客户端 名称:
2222768-84-3
Dynarrestin
4-(4-Diethylaminophenyl)-2-(2,4-difluoro-phenylamino)-thiazole-5-carboxylic acid ethyl ester
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Dynarrestin is a potent and selective reversible inhibitor of cytoplasmic dyneins 1 and 2 that inhibits dynein 1-dependent microtubule binding and motility without affecting ATP hydrolysis. It inhibits endosome movement and disturbs mitosis in cells. Dynarrestin inhibits dynein 2-mediated intraflagellar transport of the cargo IFT88 and flux of Smo within cilia. Also it inhibits cancer cells proliferation downstream of Smo.
Dynarrestin is an aminothiazole derivative, which can bind to protein tyrosine phosphatase interacting protein 51 (PTPIP51). This interaction helps in regulating various signaling pathways that lead to proliferation and migration. Dynarrestin blocks hedgehog (Hh)-dependent signaling in mouse and human cells.

基本信息

经验(实验)分子式 C22H23F2N3O2S
分子量 431.50

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 powder
颜色 white to brown
溶解性 DMSO: 2 mg/mL, clear
储存温度 2-8℃
SMILES string CCN(CC)C1=CC=C(C2=C(C(OCC)=O)SC(NC3=C(F)C=C(F)C=C3)=N2)C=C1

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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