脱羟基 LY-411575

品牌

Sigma-Aldrich

CAS

209984-56-5

货号

SML0649

包装型号

规格纯度

≥98% (HPLC)

价格

1412.42 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

209984-56-5
Deshydroxy LY-411575
Dibenzazepine
YO-01027
(S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide
GSI-XX
N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-benzeneacetamide
DBZ
γ-Secretase inhibitor XX
脱羟基 LY-411575

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

应用

Deshydroxy LY-411575 has been used in dibenzazepine (DBZ) treatment and chemical treatment.

包装

5, 25 mg in glass bottle

生化/生理作用

LY411575 prevents SPP (signal peptide peptidase) dependent cleavage of HCV (hepatitis C virus) core protein.
Deshydroxy LY-411575 is a cell-permeable γ-secretase inhibitor and inhibtor of Notch processing. Deshydroxy LY-411575 significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model and potently blocks Notch processing, with an IC₅₀of 1.7 nM in SupT1 cells.

基本信息

经验(实验)分子式	C₂₆H₂₃F₂N₃O₃
分子量	463.48
NACRES	NA.77

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 15 mg/mL, clear
储存温度	?20℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable