DDR-TRK-1

品牌

Sigma-Aldrich

CAS

1934246-19-1

货号

SML2526

包装型号

规格纯度

≥98% (HPLC)

价格

1376.29 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

1934246-19-1
DDR-TRK-1
(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoro-methyl)-phenylamino)-(5-methyl-3-(pyrimidin-5-yl)-3-aza-bicyclo[4.4.0]deca-1(6),7,9-trien-9-yl)-methanone
(4R)-1,2,3,4-Tetrahydro-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(5-pyrimidinyl)-7-isoquinolinecarboxamide

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

生化/生理作用

DDR-TRK-1 was shown to inhibit the kinase activity of Discoidin Domain Receptor 1 (DDR1) with an IC50 value of 9.4 nM. DDR receptors are linked to the progression of various human diseases, including fibrotic disorders such as pulmonary fibrosis, as well as atherosclerosis and cancer. DDR-TRK-1 showed a therapeutic effect in a mouse model of pulmonary fibrosis and inhibited Panc-1 pancreatic cancer cell colony formation and migration. DDR-TRK-1 also inhibits the TRK family kinases TRKA, TRKB, and TRKC, which are selectively expressed in neuronal tissue. DDR-TRK-1N is the negative control compound.

基本信息

经验(实验)分子式	C₂₆H₂₃F₃N₆O
分子量	492.50

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D -25 to -20°, c = 0.5 in methanol
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable