半岛bd体育手机客户端 说明
生化/生理作用
D-NMAPPD (B13), a myristoyl-CoA analog, is a cell penetrant inhibitor of N-myristoyltransferases that suppressed FRS2α (fibroblast growth factor receptor substrate 2) myristoylation. D-NMAPPD inhibits wild-type FGFRs and drug-resistant mutants (FGFRsDRM) oncogenic signaling in cancer cells. D-NMAPPD potently inhibits growth of xenograft tumors in mice. D-NMAPPD is a potent inhibitor of ceramidase that elevates endogenous ceramide levels and suppress growth of cancer cells.
基本信息
经验(实验)分子式 | C23H38N2O5 |
分子量 | 422.56 |
MDL编号 | MFCD08062172 |
半岛bd体育手机客户端 性质
测定 | ≥98% (HPLC) |
形式 | powder |
旋光性 | [α]/D -28 to -34, c = 0.1 in chloroform-d |
颜色 | white to beige |
溶解性 | DMSO: 2 mg/mL, clear |
储存温度 | 2-8℃ |
安全信息
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |