半岛bd体育手机客户端 说明
应用
CLP257 has been used as a K+- Cl-cotransporter 2 (KCC2) enhancer in human neuron culture.
包装
5, 25 mg in glass bottle
生化/生理作用
CLP257 is a selective K+-Cl?cotransporter KCC2 activator that restored impaired Cl?transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.
In streptozotocin treated rats, by activating a K+- Cl-cotransporter 2 (KCC2) in the arginine-vasopressin neuron, CLP257 mediates γ-aminobutyric acid (GABA)ergic excitation. It is however inactive with KCC1, KCC3 and KCC4.
基本信息
| 经验(实验)分子式 | C14H14FN3O2S |
| 分子量 | 307.34 |
| MDL编号 | MFCD28166488 |
| PubChem化学物质编号 | 329825822 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | , white to yellow to light brown |
| 溶解性 | DMSO: 20 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | O=C1/C(SC(N2CCCCN2)=N1)=C/C3=CC=C(F)C=C3O |
| InChI | 1S/C14H14FN3O2S/c15-10-4-3-9(11(19)8-10)7-12-13(20)17-14(21-12)18-6-2-1-5-16-18/h3-4,7-8,16,19H,1-2,5-6H2/b12-7- |
| InChI key | SKCADXVKQRCWTR-GHXNOFRVSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 |
| 预防措施声明 | P301 + P312 + P330 |
| 危险分类 | Acute Tox. 4 Oral |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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