半岛bd体育手机客户端 说明
一般描述
Cathepsin K belongs to the peptidase C1 protein family and is a lysosomal cysteine protease. The associated gene is strongly expressed on osteoclasts and is also present in cardiomyocytes. Cathepsin K is the most abundant and main protease involved with osteoclastic activity.
生化/生理作用
Cathepsin K is responsible for collagenolytic and elastolytic activities. It can degrade type II collagen and thus participates in the degradation of articular cartilage. It also plays an important role in osteoarthritis and periodontitis. Removal of the cathepsin K activity provides protection against agents inducing metabolic stress in the heart. Absence of cathepsin K also protects from age-related decline in cardiac function by inhibition of caspase-associated and caspase-independent cell death.
外形
0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.
基本信息
| NACRES | NA.32 |
半岛bd体育手机客户端 性质
| 生物来源 | mouse |
| 重组 | expressed inE. coli |
| 测定 | ≥90% (SDS-PAGE) |
| 形式 | liquid |
| 分子量 | 23.4 kDa (115-329 aa) |
| 包装 | pkg of 5 μg pkg of 50 μg |
| 浓度 | 0.5 mg/mL |
| UniProt登记号 | P55097 |
| 运输 | dry ice |
| 储存温度 | ?70℃ |
| Gene Information | mouse ... CTSK(13038) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
