C16-02:0 PC

半岛bd体育手机客户端 说明

一般描述

C16-02:0 PC, also referred as 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (C16 PAF) (acetyl PAF), is a platelet-activating factor (PAF). Acetyl PAF is a natural PAF with ether-linked hexadecyl chain at the sn-1 position and an acetyl group at the sn-2 position.

应用

C16-02:0 PC or 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine may be used as a substrate in enzymatic lipoprotein-associated phospholipase A2 (Lp-PLA2) activity assay. It may also be used to study its physicochemical properties and its interaction with peptides derived from the C-terminal domains of human apolipoprotein E.

生化/生理作用

C16-02:0 PC, a platelet-activating factor and a lipid mediator is involved in various inflammatory diseases. It facilitates initiation and progression of atherosclerosis. PAF acts as a potential biomarker for coronary artery diseases. It exhibits its activity by binding to a specific PAF receptor, which belongs to the seven transmembrane-spanning G-protein-linked receptors family. PAF on hydrolysis by platelet-activating factor-acetyl hydrolase produces LysoPAF (1-O-alkyl-2-hydroxy-sn-glycero-3-phosphocholine).

包装

5 mL Clear Glass Sealed Ampule (878110P-25mg)
5 mL Clear Glass Sealed Ampule (878110P-5mg)

基本信息

经验(实验)分子式	C26H54NO7P
分子量	523.68
NACRES	NA.25

半岛bd体育手机客户端 性质

形式	powder
包装	pkg of 1 × 25 mg (878110P-25mg) pkg of 1 × 5 mg (878110P-5mg)
manufacturer/tradename	Avanti Polar Lipids 878110P
运输	dry ice
储存温度	?20℃
SMILES string	[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(C)=O)COCCCCCCCCCCCCCCCC)=O
InChI	1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1
InChI key	HVAUUPRFYPCOCA-AREMUKBSSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable