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BMH-21

品牌
Sigma-Aldrich
CAS
896705-16-1
货号
SML1183
规格纯度
≥98% (HPLC)
价格
1117.23 *本价格含增值税费
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半岛bd体育手机客户端 名称:
896705-16-1
BMH-21
N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

BMH-21 is a planar heterocyclic small molecule DNA intercalator.

应用

BMH-21 has been used in cell culture.

包装

5, 25 mg in glass bottle

生化/生理作用

BMH-21 is a potent inhibitor of RNA Pol I. BMH-21 binds strongly to GC-rich DNA sequences, ultimately inhibiting RNA Pol I, blocking transcription and disrupting the nucleolar structure. BMH-1 causes dissociation of the RPA194 catalytic subunit from Pol I, and disassembly of Pol I:DNA complexes. The compound BMH-21 inhibits proliferation of a broad range of tumor cell lines.
BMH-21 has the ability to bind ribosomal DNA and prevent RNA polymerase I (Pol I) transcription and results in the disintegration of the nucleolus. It does not impair DNA damage detection. BMH-21 is considered as an important activator of the p53 pathway.

基本信息

经验(实验)分子式 C21H20N4O2
分子量 360.41
MDL编号 MFCD27225377
PubChem化学物质编号 329825705
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 faint yellow to dark orange
溶解性 DMSO: 1 mg/mL, clear (warmed)
储存温度 2-8℃
SMILES string O=C(N(C=CC=C1C(NCCN(C)C)=O)C1=N2)C(C2=C3)=CC4=C3C=CC=C4
InChI 1S/C21H20N4O2/c1-24(2)11-9-22-20(26)16-8-5-10-25-19(16)23-18-13-15-7-4-3-6-14(15)12-17(18)21(25)27/h3-8,10,12-13H,9,11H2,1-2H3,(H,22,26)
InChI key BXYDVWIAGDJBEC-UHFFFAOYSA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302
危险分类 Acute Tox. 4 Oral
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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