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位置: 首页> 品牌> Sigma-Aldrich> N-[(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-[1,1′-biphenyl]-4-carboxamide trifluoroacetate

BB-Cl-amidine trifluoroacetate salt

品牌
Sigma-Aldrich
货号
SML2250
规格纯度
≥98% (HPLC)
价格
1086.43 *本价格含增值税费
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半岛bd体育手机客户端 名称:
BB-Cl-amidine trifluoroacetate salt
N-[(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-[1,1′-biphenyl]-4-carboxamide trifluoroacetate
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

BB-Cl-amidine is an irreversible pan-protein-arginine deiminase (PAD) inhibitor (kinact/KI in M-1min-1= 16100/PAD1, 4100/PAD2, 6800/PAD3, 13300/PAD4) with >20-fold increased potency against U2OS osteosarcoma cutlures (viability assay IC50 = 8.8 μM vs >200 μM with Cl-amidine) and longer in vivo half-life (1.75 hrs vs 15 min for Cl-amidine in plasma post injection in mice) than Cl-amidine. BB-Cl-amidine effectively inhibits PMA-induced neutrophils extracellular trap (NET) formation from lupus-prone MRL/lpr mice-derived bone marrow neutrophils in cultures (by 78% and 34% with 20 μM BB-Cl-amidine or Cl-amidine, respectively), while daily s.c. injection (1 mg/kg) is efficacious in ameliorating lupus symptoms in in MRL/lprmicein vivo.

基本信息

经验(实验)分子式 C26H26ClN5O · xC2HF3O2
分子量 459.97 (free base basis)
NACRES NA.77

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 powder
储存条件 desiccated
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 ?20℃
SMILES string O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N[C@H](C3=NC4=C(N3)C=CC=C4)CCCNC(CCl)=N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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