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位置: 首页> 品牌> Sigma-Aldrich> (E)-5α-Stigmasta-7,22-dien-3β-ol

α-Spinasterol

(E)-5α-Stigmasta-7,22-dien-3β-ol

品牌
Sigma-Aldrich
CAS
481-18-5
货号
SML2232
规格纯度
≥98% (HPLC)
价格
1055.93 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
481-18-5
α-Spinasterol
α-Spinasterin
Hitodesterol
Spinasterol
(E)-5α-Stigmasta-7,22-dien-3β-ol
5α-Stigmasta-7,22-dien-3β-ol
Bessisterol
(3β,5α,22E)-Stigmasta-7,22-dien-3-ol
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

α-Spinasterol is a blood-brain barrier-permeable and orally active plant phytosterol with antioxidant, anticonvulsant (0.1-1 mg/kg i.p. in mice), antidepressant (1-2 mg/kg i.p. in mice) and anti-inflammatory (0.001-1 mg/kg, i.p. or 1-10 mg/kg, i.g. in mice) properties, as well as antinociceptive efficacyviadual actions against transient receptor potential vanilloid 1 (TrpV1; IC50/Emax = 1.4 μM/67% against 2 nM RTX for binding mouse spinal cord membranes; IC50/Emax = 40 μM/62% against 20 μM capsaicin-induced mouse spinal cord synaptosomes Ca2+ influx) and cyclooxygenases (IC50 = 16.17 μM/COX1 and 7.76μM/COX2). a-spinasterol can directly affect membrane structure and packing in a manner similar to cholesterol, both a-spinasterol and stitosterol are reported to lower plasma/liver cholesterol levels and increase fecal cholesterol excretion when supplemented in daily diet (1%) in micein vivo.
α-Spinasterol is a constituent of argan oil. It regulates nuclear receptors expression and modulates mitochondrial function. It mimics natural cholesterol and its functionality. α-Spinastero lelicits cytoprotective and antiulcerogenic functionality. It has therapeutic potential towards diabetic nephropathy.

基本信息

经验(实验)分子式 C29H48O
分子量 412.69
MDL编号 MFCD00200554

半岛bd体育手机客户端 性质

生物来源 Aster scaber
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 ethanol: 2 mg/mL, clear (warmed)
储存温度 ?20℃
SMILES string C[C@@]12[C@](CC[C@]2([H])[C@H](C)/C=C/[C@@H](CC)C(C)C)([H])C3=CC[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC1
InChI 1S/C29H48O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h8-9,11,19-23,25-27,30H,7,10,12-18H2,1-6H3/b9-8+/t20-,21-,22+,23+,25-,26+,27+,28+,29-/m1/s1
InChI key JZVFJDZBLUFKCA-FXIAWGAOSA-N

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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