N<SUP>7</SUP>-[(1′R,2′S,3′R,4′S)-2′,3′-dihydroxy-4′-aminocyclopentyl]-4-amino-5-iodopyrrolopyrimidine dihydrochloride hydrate

N⁷-[(1′R,2′S,3′R,4′S)-2′,3′-dihydroxy-4′-aminocyclopentyl]-4-amino-5-iodopyrrolopyrimidine dihydrochloride hydrate

品牌

Sigma-Aldrich

货号

A2846

包装型号

5 MG, ≥98% (HPLC), solid

规格纯度

≥98% (HPLC), solid

价格

4334.02 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

A-134974 dihydrochloride hydrate
N ⁷-[(1′R,2′S,3′R,4′S)-2′,3′-dihydroxy-4′-aminocyclopentyl]-4-amino-5-iodopyrrolopyrimidine dihydrochloride hydrate

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

包装

5 mg in glass bottle

生化/生理作用

A-134974 is a novel and selective adenosine kinase (AK) inhibitor with IC₅₀= 60 pM. Systemic A-134974 (i.p.) dose dependently reduced hyperalgesia (ED₅₀= 1 μmol/kg) and at higher doses, reduced locomotor activity (ED₅₀= 16 μmol/kg). Administration of A-134974 intrathecally (i.t.) was more potent (ED₅₀= 6 nmol) at producing antihyperalgesia than delivering the compound by intracerebralventricular (ED₅₀= 100 nmol, i.c.v.) or intraplantar (ED₅₀>300 nmol) routes. In contrast, i.c.v. administration of A-134974 was more effective in reducing locomotor activity than i.t. administration (ED₅₀values were 1 and >100 nmol, respectively). Increasing the pretreatment time for i.t.-delivered A-134974 caused a greater reduction in locomotor activity (ED₅₀= 10 nmol). This was due to diffusion of A-134974 (i.t.) to supraspinal sites. These data demonstrate that the novel AK inhibitor A-134974 potently reduces thermal hyperalgesia primarily through interactions with spinal sites, whereas its ability to depress locomotor activity is predominantly mediated by supraspinal sites.

特点和优势

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold under license from Abbott Laboratories.

基本信息

经验(实验)分子式	C₁₁H₁₄IN₅O₂· 2HCl · xH₂O
分子量	448.09 (anhydrous basis)
MDL编号	MFCD08692561
PubChem化学物质编号	24890697
NACRES	NA.77

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
颜色	off-white to light tan
溶解性	H₂O: soluble
创始人	Abbott
SMILES string	O.Cl.Cl.N[C@H]1C[C@H]([C@H](O)[C@@H]1O)n2cc(I)c3c(N)ncnc23
InChI	1S/C11H14IN5O2.2ClH.H2O/c12-4-2-17(6-1-5(13)8(18)9(6)19)11-7(4)10(14)15-3-16-11;;;/h2-3,5-6,8-9,18-19H,1,13H2,(H2,14,15,16);2*1H;1H2/t5-,6+,8+,9-;;;/m0.../s1
InChI key	INMLNTBMPNIKQK-HWZUHWJPSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

A-134974 dihydrochloride hydrate

N7-[(1′R,2′S,3′R,4′S)-2′,3′-dihydroxy-4′-aminocyclopentyl]-4-amino-5-iodopyrrolopyrimidine dihydrochloride hydrate

N⁷-[(1′R,2′S,3′R,4′S)-2′,3′-dihydroxy-4′-aminocyclopentyl]-4-amino-5-iodopyrrolopyrimidine dihydrochloride hydrate