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位置: 首页> 品牌> Sigma-Aldrich> 4-[1,1′-Biphenyl]-4-yl-3,4-dihydro-6-methyl-2-oxo-5-[(phenylmethoxy)carbonyl]-1(2H)-pyrimidinehexanoic acid

116-9e

品牌
Sigma-Aldrich
CAS
831217-43-7
货号
E1036
规格纯度
≥98% (HPLC), powder
价格
1491.95 *本价格含增值税费
促销
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半岛bd体育手机客户端 名称:
831217-43-7
116-9e
4-[1,1′-Biphenyl]-4-yl-3,4-dihydro-6-methyl-2-oxo-5-[(phenylmethoxy)carbonyl]-1(2H)-pyrimidinehexanoic acid
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

116-9e has been used as an inhibitor of heat shock protein 70 (Hsp70) co-chaperone HDJ2 (human Ydj1/DNAJA1) to study the influence of HDJ2 on the regulation of ribonucleotide reductase (RNR) activity in HEK293 cells. It has also been used as an Hsp70 inhibitor to study the effect of Hsp70 chaperone on b5‐ops glycosylation in the side populations (SP) HeLa cells.

包装

5, 25 mg in glass bottle

生化/生理作用

116-9e is a dihhydropyrimidine compound.
116-9e is a blocker of Hsp40-Hsp70 binding thereby inhibiting the chaperone activity of Hsp70-Hsp40. The Hsp40 family of co–chaperones binds to Hsp70 through a conserved J–domain. It is believed that 116-9e inhibits chaperone functions by preventing Hsp70–Hsp40 complex assembly.

The same compound by a different name, MAL2-11B, has been found to inhibit the activity of a viral J-domain protein, large tumor antigen (TAg). MAL2-11B inhibited both TAg′s endogenous ATPase activity and the TAg-mediated activation of Hsp70.

基本信息

经验(实验)分子式 C31H32N2O5
分子量 512.60
MDL编号 MFCD18632539
PubChem化学物质编号 329798875
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to off-white
溶解性 DMSO: >20 mg/mL
储存温度 2-8℃
SMILES string CC1=C(C(NC(=O)N1CCCCCC(O)=O)c2ccc(cc2)-c3ccccc3)C(=O)OCc4ccccc4
InChI 1S/C31H32N2O5/c1-22-28(30(36)38-21-23-11-5-2-6-12-23)29(32-31(37)33(22)20-10-4-9-15-27(34)35)26-18-16-25(17-19-26)24-13-7-3-8-14-24/h2-3,5-8,11-14,16-19,29H,4,9-10,15,20-21H2,1H3,(H,32,37)(H,34,35)
InChI key GHFQWLNXJMUCGC-UHFFFAOYSA-N

安全信息

象形图 GHS06GHS09
警示用语: Danger
危险声明 H301 - H410
预防措施声明 P273 - P301 + P310 + P330
危险分类 Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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